Sitagliptin + Metformin Hydrochloride is used in addition to diet and exercise to improve blood sugar control in adults with type 2 diabetes.
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Taglimet 50/500mg Tablet (Sitagliptin 50mg + Metformin Hydrochloride 500mg) is a combination drug used to treat type 2 diabetes. This condition arises when the body either doesn't produce enough insulin or when there is resistance to the action of insulin, leading to elevated blood sugar levels.
Sitagliptin is classified as a dipeptidyl peptidase-4 (DPP-4) inhibitor. It works by increasing the levels of certain natural substances that help lower blood sugar when it is high. On the other hand, Metformin belongs to the class of biguanides and acts by reducing glucose production in the liver, delaying glucose absorption in the intestines, and improving the body's sensitivity to insulin. Together, these drugs prevent blood glucose levels from spiking significantly after meals.
To minimize the risk of an upset stomach, it's recommended to take Taglimet 50/500mg Tablet with food at the same time each day for optimal results. The appropriate dosage will be determined by your doctor and may change depending on your condition.
One common side effect of this medication is hypoglycemia, which is characterized by symptoms like dizziness, sweating, palpitations, hunger pangs, dry mouth, and skin changes. To avoid hypoglycemia, it's essential not to skip meals and carry a source of sugar with you.
METFORMIN+SITAGLIPTIN should not be discontinued even if you start feeling better without consulting your doctor, as blood sugar levels can fluctuate. Abruptly stopping the medication could raise sugar levels, increasing the risk of complications like retinopathy, nephropathy, and neuropathy.
It is important to inform your doctor if you have any type of heart disease or if you are pregnant, planning to become pregnant, or breastfeeding. Additionally, the medication is not suitable for those with type 1 diabetes mellitus or severe kidney or liver disease. Always seek professional medical advice and follow your doctor's recommendations to manage your diabetes effectively.
Avoid consumption of alcohol while takingTaglimet 50/500mg Tablet as it may increase the risk of unwanted side effects.
Taglimet 50/500mg Tablet is not recommended during pregnancy unless absolutely necessary. If you are pregnant, consult your doctor to understand the benefits and potential risks before taking this medicine.
This medicine can pass through breastmilk and can cause harm to the breastfed baby if taken by lactating mother. This medicine should not be taken by lactating mother.
Do not drive or operate any machines if you feel dizzy after taking Taglimet 50/500mg Tablet.
Taglimet 50/500mg Tablet is not recommended for use in patients with severely reduced kidney functions. Therefore, consult your doctor before taking it.
If you have or had a history or evidence of any liver-related diseases, please consult the doctor before taking medicine.
Type 2 Diabetes Mellitus
Taglimet 50/500mg Tablet is a combination of Metformin and Sitagliptin. Metformin works by increasing the action of insulin (a hormone that keeps the blood sugar at an appropriate level) in the body, decreasing the absorption of sugar from the intestine, and decreasing the production of sugar in the liver. Sitagliptin works by increasing the production of a hormone known as insulin, which further helps in decreasing the excessive sugar level in the blood.
Taglimet 50/500mg Tablet is a combination of Metformin and Sitagliptin. It is used to treat type II diabetes in adults (the inability of a hormone known as insulin to reduce the abnormally increased blood sugar levels). It works by increasing the amounts of a hormone known as insulin, which helps in decreasing the excessive sugar level in the blood. It also reduces sugar production in the liver.
This medication is a combination of two antihyperglycemic drugs that work together to improve glycemic control in patients with type 2 diabetes. The two active ingredients are Metformin HCl, a biguanide, and Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor.
Sitagliptin acts by reducing the inactivation of incretin hormones, such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). These hormones are released by the intestine in response to meals and stimulate insulin production and release from pancreatic beta cells. GLP-1 also inhibits the secretion of glucagon from pancreatic alpha cells, leading to decreased hepatic glucose synthesis. By enhancing insulin release and reducing glucagon levels, Sitagliptin helps maintain glucose levels in a glucose-dependent manner.
Metformin HCl, on the other hand, works differently from other oral antihyperglycemic drugs. It inhibits the synthesis of glucose in the liver, reducing the amount of glucose released into the bloodstream.
By combining Sitagliptin and Metformin HCl, this medication addresses multiple aspects of glucose regulation in the body. Sitagliptin enhances insulin release, reduces glucagon levels, and promotes glucose-dependent responses, while Metformin HCl limits glucose production in the liver. This complementary mode of action helps patients with type 2 diabetes better manage their blood sugar levels and improve overall glycemic control.
The recommended adult dose of Taglimet 50/500mg Tablet for the treatment of type 2 diabetes mellitus is as follows:
For patients not currently treated with Metformin:
For patients already treated with Metformin:
For patients taking Metformin 850 mg twice daily:
The dosing may be adjusted based on effectiveness and tolerability, but the maximum daily dose should not exceed Sitagliptin 100 mg and Metformin 2000 mg.
If you are using the extended-release tablet:
It is essential to consider any hepatic impairment, as this combination should not be administered to patients with hepatic impairment.
Always follow your doctor's instructions and do not stop taking Taglimet 50/500mg Tablet without consulting your physician. Take the medicine with a glass of water and avoid crushing or chewing the tablet.
Sitagliptin + Metformin Hydrochloride can interact with several other drugs, potentially affecting their efficacy or causing adverse effects. Some of these interactions include:
Consuming excessive alcoholic beverages while taking Sitagliptin + Metformin Hydrochloride may increase the risk of a serious condition called Lactic Acidosis, so it's essential to avoid alcohol.
There are specific drug-disease interactions to consider as well. People with heart diseases such as congestive heart failure and myocardial infarction, those with Vitamin B12 deficiency, and individuals with alcoholism should avoid taking Sitagliptin + Metformin Hydrochloride.
Always inform your healthcare provider about any medications you are taking, including over-the-counter drugs, herbal supplements, and vitamins, to ensure safe and effective treatment. Additionally, follow your doctor's advice and adhere to prescribed dosages to manage your condition effectively.
The pregnancy classification for Sitagliptin + Metformin Hydrochloride is Category B. This indicates that no adequate and well-controlled trials have been conducted with Sitagliptin Phosphate Monohydrate INN/Metformin Hydrochloride BP in pregnant women. Therefore, the safety of this medication during pregnancy is not fully known.
The use of Sitagliptin + Metformin Hydrochloride during pregnancy should only be considered if absolutely necessary, and the potential benefits must outweigh the potential risks. If you are pregnant or planning to become pregnant, it is crucial to discuss the use of this medication with your doctor. They can assess your individual situation and provide guidance on the most appropriate treatment options to manage your condition safely during pregnancy.
Always follow your doctor's advice, inform them of your medical history, and report any unusual symptoms or reactions while taking Sitagliptin + Metformin Hydrochloride. This will help ensure safe and effective management of your diabetes and overall health.
Store Taglimet 50/500mg Tablet at a temperature not above 30°C in a cool and dry place. Keep it out of the reach of children and pets.
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